Arizona Cardinals vs Seattle Seahawks prediction: 5 of 5 AI models back Seattle Seahawks

Synthesis

All five experts back Seattle, and they agree on the shape of the game. Seattle has the better defense, home field and the best skill player on the field in Jaxon Smith-Njigba. Arizona has the league's worst scoring defense, at about 29.8 points allowed per game. Seattle won the Week 2 meeting 31-7, and Lock threw for 235 yards and three touchdowns against this defense in that game.

The experts also agree that this is not a comfortable Seattle spot. The Friday injury reports, which the web search confirms, rule out Sam Darnold, Charles Cross, Quenton Nelson and Rashid Shaheed, along with defensive linemen Leonard Williams and Brandon Pili and edge Uchenna Nwosu. Drew Lock starts with a sore elbow behind a rebuilt left side of the line, on a short week after a Monday night home loss to Chicago. Arizona's own reports rule out left tackle Jayden Williams, right guard Jon Gaines II and running back Bam Knight. That leaves Gardner Minshew starting behind a patched-up line, but with recent rhythm after his three-touchdown relief outing in Dallas.

Resolving the disagreements

The experts differ mainly on margin, not on the winner. Claude and Grok lean on Arizona's defense being so poor that Seattle only needs a couple of touchdowns. GPT and Kimi stress that Seattle's thinner protection and pass rush make a two-score win harder. DeepSeek adds a red-zone point: Seattle's offense finishes poorly and its defense allows touchdowns at a high rate, so Arizona can score even with few possessions. I weight these roughly equally, since the models' recent accuracy is close. The synthesis is a Seattle win by about a touchdown. Seattle's defensive baseline and Arizona's weak defense and depleted skill group outweigh the injuries. But the shorthanded offensive line and Lock's elbow cap Seattle's ceiling, and rain or wind would trim the possession count.